Background: An infectious disease caused by a novel coronavirus called COVID-19 has raged across the world since December 2019. The novel coronavirus first appeared in Wuhan, China, and quickly spread to Asia and now many countries around the world are affected by the epidemic. The deaths of many patients, including medical staff, caused social panic, media attention, and high attention from governments and world organizations. Today, with the joint efforts of the government, the doctors and all walks of life, the epidemic in Hubei Province has been brought under control, preventing its spread from affecting the lives of the people. Because of its rapid spread and serious consequences, this sudden novel coronary pneumonia epidemic has become an important social hot spot event. Through the analysis of the novel coronary pneumonia epidemic situation, we can also have a better understanding of sudden infectious diseases in the future, so that we can take more effective response measures, establish a truly predictable and provide reliable and sufficient information for prevention and control model. Methods: We establish different models according to the different developments of the epidemic situation, different time points, and different response measures taken by the government. To be specific, during the period of 2020.1.23-2020.2.7, the traditional SIR model is adopted; during the period of 2020.2.8-2020.3.30, according to the scientific research results, it was considered that the novel coronary pneumonia has a latent period, so in the later phase of epidemic development, the government has effectively isolated patients, thus we adopt the SEIQR model accordingly. During the period of 2020.3.31-2020.5.16, because more asymptomatic infected people were found, we use the SEIQLR model to fit. Finally, through a SEIR simulator, considering the susceptible number, the latent number, the infected number, the cured number, death number and other factors, we simulate the change of various numbers of people from the beginning to the next 180 days of novel coronary pneumonia. Findings: The results based on the analysis of differential equations and kinetic models show that through the prediction of the model established in the first phase, the epidemic situation of novel coronary pneumonia in Hubei Province was controlled at the end of March, which is in line with the actual situation. The rest of Hubei province, except for Wuhan, lifted control of the departure channel from 0:00 am on March 25, and Wuhan was also unblocked on April 8. Through the establishment of the second-phase model, it is found that the epidemic situation will reach its peak in mid-February. For example, the quarantine admission of the hospital declined after mid-February, which is inseparable from the measures to build square cabin hospitals in early February so that more and more patients can be admitted. The model established in the third phase shows that the epidemic had been completely controlled by the end of May, which is also in line with the reality. Because in mid-May, the Wuhan government conducted a nucleic acid test on all the citizens to screen for asymptomatic infected persons to fundamentally control the spread of novel coronary pneumonia. Interpretation: Hubei Province, as the center of the initial outbreak of novel coronary pneumonia, people were forced to be isolated at home during the Spring Festival, the most important Chinese holiday, and the whole society was in a state of suspension of work and study. The Chinese government had taken many measures in response to the epidemic, such as shutting down the city, vigorously building square cabin hospitals, and prohibiting people from gathering. At the beginning of May this year, the epidemic in Hubei Province was finally effectively controlled. For ordinary citizens, we should not cause unnecessary panic about the unknown novel coronavirus. Instead, we should fully understand and be familiar with this virus. In addition to the relevant medical knowledge, we should also understand the spread of infectious diseases through appropriate mathematical models. By mathematical models, we can understand the degree of harm of infectious diseases, when to control it, how to stop it, and use scientific views to reveal the original face of the novel coronavirus to the public without causing social panic.

Introduction: Intestinal intussusception corresponds to invagination of one segment inside another. Although rare in adults, it corresponds to 1% of cases involving intestinal obstruction, being more common in the small intestine. The objective of this study is to report a case of intestinal intussusception secondary to lipoma. Case Report: female patient 51 years was admitted to the emergency room with a colicky abdominal pain for 1 month, no irradiation, and with worsening for 2 days, associated with nausea, vomiting and hematochezia. On physical examination, distended and hypertympanic abdomen with pain to palpation and rectal touch with melena was observed. Acute abdominal X-ray demonstrated evidence of colonic loop dilation and hydro-air level. Computed tomography examination of abdomen and pelvis demonstrated a target lesion suggesting intussusception, confirmed in the intraoperative by invagination from the terminal ileum to the proximal descending colon with subtotal colectomy and terminal ileostomy. Discussion: Intussusception in adults usually occurs secondary to a point of advance, either by benign tumors, malignant or motility disorders. In the large intestine, lipoma is considered a rare cause of invagination, and malignant tumors are more common, and its symptomatology and risks of complications are mainly related to the size of the lesion. Conclusion: The colic submucosal intraluminal lipoma is a rare cause of intestinal intussusception and is usually an intraoperative diagnosis.

Legionella pneumophilla represents a relatively common cause of community acquired pneumonia with high mortality related burden if not promptly diagnosed and treated with appropriate antibiotics. Clinical characteristics of Legionella infection are often non-specific making accurate diagnosis challenging. Here we report a case of a middle aged immunocompetent woman with a history of fever and abdominal pain located in the right upper abdomen. The paucity of respiratory symptoms led initially to an altered presumed diagnosis of acute cholecystitis. Initial diagnostic work up disclosed elevation of inflammation markers such as raised erythrocyte sedimentation rate (ESR) and C reactive protein (CRP) with acute acalculous cholecystitis. Development of pulmonary symptoms during hospitalization raised the suspicion of Legionella community acquired pneumonia with parapneumonic effusion which was later confirmed by urine for legionella antigen. She started treatment with clarithromycin and improved dramatically.

Phosphaturic mesenchymal tumour is a unique neoplasm of bone and soft tissue delineating diverse, specific histological features along with production of FGF-23 and associated metabolic bone defects such as rickets and osteomalacia. Paraneoplastic syndrome engendered by the neoplasm is associated with an acquired variant of oncogenic osteomalacia (OO), which can also appear in diverse mesenchymal neoplasia. Reoccurring tumefaction with oncogenic osteomalacia (OO) can emerge within sites such as mandible along with pulmonary and soft tissue metastasis.

We analysed retinal nerve fibre layer (RNFL) thickness of 38 adults with Human Immunodeficiency Virus infection without any retinopathy on fundus examination, using Spectralis HRAOCT, after ruling out glaucoma. Mean age of the population was 36.2±8.17 years, and mean CD4 count was 325.7±159.3. Significant thinning of RNFL was noted in 47.3% patients, with predominant involvement of the temporal retina. No significant association could be found with CD4 cell count or age (p=0.22and 0.42 respectively).